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Breast Carcinoma In Situ

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Overview

NCI Definition: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [1]

Breast carcinoma in situs most frequently harbor alterations in TP53, PIK3CA, ESR1, NF1, and MAP3K1 [2].

Most Commonly Altered Genes in Breast Carcinoma In Situ

PIK3CA Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and PIK3CA Codon 1047 Missense are the most common alterations in breast carcinoma in situ [2].

Top Alterations in Breast Carcinoma In Situ

Clinical Trials

View Clinical Trials for Breast Carcinoma In Situ

Disease Details

Synonyms
Non-Invasive Carcinoma of Breast, stage 0 breast carcinoma in situ, Non-Invasive Breast Carcinoma, Stage 0 Breast Cancer AJCC v7, Non-Infiltrating Breast Carcinoma, Carcinoma in situ of Breast, Non-Infiltrating Carcinoma of Breast, Stage 0 Breast Cancer AJCC v6, Stage 0 Carcinoma of the Breast, Non-Infiltrating Carcinoma of the Breast, Stage 0 Breast Carcinoma, Breast Cancer Stage 0, Breast Cancer in situ, Breast Carcinoma in situ, Non-Invasive Carcinoma of the Breast, Carcinoma in situ of the Breast, Stage 0 Carcinoma of Breast, Stage 0 Breast Cancer, In situ Breast Cancer
Parent(s)
Carcinoma In Situ
Children
Lobular Neoplasia, Ductal Carcinoma In Situ, and Breast Lobular Carcinoma In Situ

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.