NCI Definition: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [1]

Breast carcinoma in situs most frequently harbor alterations in TP53, PIK3CA, ESR1, NF1, and MAP3K1 [2].

Most Commonly Altered Genes in Breast Carcinoma In Situ

PIK3CA Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and PIK3CA Codon 1047 Missense are the most common alterations in breast carcinoma in situ [2].

Top Alterations in Breast Carcinoma In Situ

Disease Details

Non-Invasive Carcinoma of Breast, stage 0 breast carcinoma in situ, Non-Invasive Breast Carcinoma, Stage 0 Breast Cancer AJCC v7, Non-Infiltrating Breast Carcinoma, Carcinoma in situ of Breast, Non-Infiltrating Carcinoma of Breast, Stage 0 Breast Cancer AJCC v6, Stage 0 Carcinoma of the Breast, Non-Infiltrating Carcinoma of the Breast, Stage 0 Breast Carcinoma, Breast Cancer Stage 0, Breast Cancer in situ, Breast Carcinoma in situ, Non-Invasive Carcinoma of the Breast, Carcinoma in situ of the Breast, Stage 0 Carcinoma of Breast, Stage 0 Breast Cancer, In situ Breast Cancer
Carcinoma In Situ
Lobular Neoplasia, Ductal Carcinoma In Situ, and Breast Lobular Carcinoma In Situ


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.