Overview

Breast invasive ductal carcinomas most frequently harbor alterations in TP53, PIK3CA, ERBB2, GATA3, and CCND1 [2].

Most Commonly Altered Genes in Breast Invasive Ductal Carcinoma

TP53 Mutation, PIK3CA Mutation (somatic), PIK3CA Mutation, TP53 c.217-c.1178 Missense, and TP53 c.142-c.212 Missense are the most common alterations in breast invasive ductal carcinoma [2].

Top Alterations in Breast Invasive Ductal Carcinoma

Significant Genes in Breast Invasive Ductal Carcinoma

ERBB2 +

Disease Details

Parent(s)
Breast Ductal Carcinoma
Children
Lipid-Rich Breast Carcinoma, Acinic Cell Breast Carcinoma, Tubular Breast Carcinoma, Secretory Breast Carcinoma, Invasive Apocrine Breast Carcinoma, Medullary Breast Carcinoma, Invasive Ductal Carcinoma, Not Otherwise Specified, and Mucinous Breast Carcinoma
OncoTree Name
Breast Invasive Ductal Carcinoma
OncoTree Code
IDC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.