Diseases /
Breast Invasive Lobular Carcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures. [1]
Breast invasive lobular carcinomas most frequently harbor alterations in CDH1, PIK3CA, TP53, CCND1, and ERBB2 [2].
PIK3CA Mutation, CDH1fs, CDH1 Mutation, PIK3CA Codon 1047 Missense, and PIK3CA H1047R are the most common alterations in breast invasive lobular carcinoma [2].
Clinical Trials
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.