Overview

NCI Definition: An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures. [1]

Breast invasive lobular carcinomas most frequently harbor alterations in CDH1, PIK3CA, TP53, CCND1, and ERBB2 [2].

Most Commonly Altered Genes in Breast Invasive Lobular Carcinoma

PIK3CA Mutation, CDH1fs, CDH1 Mutation, PIK3CA Codon 1047 Missense, and PIK3CA H1047R are the most common alterations in breast invasive lobular carcinoma [2].

Top Alterations in Breast Invasive Lobular Carcinoma

Significant Genes in Breast Invasive Lobular Carcinoma

ERBB2 +

Disease Details

Synonyms
Infiltrating Lobular Carcinoma of Breast, Invasive Lobular Breast Carcinoma, Infiltrating Lobular Breast Carcinoma, Infiltrating Lobular Carcinoma of the Breast, Infiltrating Lobular Adenocarcinoma, Invasive Lobular Adenocarcinoma, Invasive Lobular Carcinoma, Invasive Lobular Carcinoma of Breast, Breast invasive lobular carcinoma (ILC), Classic Invasive Lobular Carcinoma, Invasive Lobular Carcinoma, Classic Type, Invasive Lobular Carcinoma of the Breast
Parent(s)
Lobular Breast Carcinoma
OncoTree Name
Breast Invasive Lobular Carcinoma
OncoTree Code
ILC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.