Overview

NCI Definition: An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. [1]

Breast invasive lobular carcinomas most frequently harbor alterations in CDH1, PIK3CA, TP53, ERBB2, and CCND1 [2].

Most Commonly Altered Genes in Breast Invasive Lobular Carcinoma

CDH1 Mutation, PIK3CA Mutation, PIK3CA H1047R, TP53 Mutation, and CCND1 Amplification are the most common alterations in breast invasive lobular carcinoma [2].

Top Alterations in Breast Invasive Lobular Carcinoma

Significant Genes in Breast Invasive Lobular Carcinoma

ERBB2 +

Disease Details

Synonyms
Lobular Carcinoma, Lobular Carcinoma of Breast, Lobular Breast Carcinoma, Lobular Adenocarcinoma, Lobular Carcinoma of the Breast, Breast invasive lobular carcinoma (ILC)
Parent(s)
Lobular Breast Carcinoma
OncoTree Name
Breast Invasive Lobular Carcinoma
OncoTree Code
ILC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.