Overview

NCI Definition: A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma. [1]

Significant Genes in Breast Lobular Carcinoma In Situ

BRCA1 +

BRCA2 +

ERBB2 +

PTEN +

TP53 +

Disease Details

Synonyms
Lobular Ca in situ of Breast, Lobular Ca in situ of the Breast, Non-Invasive Lobular Carcinoma of the Breast, Lobular Carcinoma in situ of Breast, Lobular Breast Carcinoma In Situ, Non-invasive lobular breast carcinoma, Lobular Carcinoma In Situ of the Breast, Non-Infiltrating Lobular Carcinoma of the Breast, Non-Invasive Lobular Breast Carcinoma, Lobular Carcinoma In Situ of the Breast (LCIS, Non-infltrating lobular breast carcinoma, Non-Infiltrating Lobular Carcinoma, lobular carcinoma in situ, Lobular Carcinoma in situ, Non-Infiltrating Lobular Breast Carcinoma, Lobular carcinoma in situ, LCIS, Lobular Carcinoma In Situ (LCIS), Non-Invasive Lobular Carcinoma of Breast, Non-Infiltrating Lobular Carcinoma of Breast
Parent(s)
Adenocarcinoma In Situ
OncoTree Name
Breast Lobular Carcinoma In Situ
OncoTree Code
LCIS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.