Overview

NCI Definition: The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [1]

Significant Genes in Burkitt Leukemia

ABL1 +

AFF1 +

BCL2 +

BCL6 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

NUP214 +

PBX1 +

RPN1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Burkitt's Leukemia, L3 Acute Lymphoblastic Leukemia, L3 Acute Lymphogenous Leukemia, Burkitt lymphoma/leukemia, L3 Acute Lymphocytic Leukemia, Burkitt's Cell Leukemia, L3 Acute Lymphoid Leukemia, FAB L3
Parent(s)
Lymphoid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.