Overview

NCI Definition: The leukemic counterpart of Burkitt's lymphoma. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [1]

Significant Genes in Burkitt Leukemia

ABL1 +

AFF1 +

BCL2 +

BCL6 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

NRIP3 +

NUP214 +

PBX1 +

RPN1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Burkitt lymphoma/leukemia, Burkitt's Cell Leukemia, L3 Acute Lymphoid Leukemia, L3 Acute Lymphogenous Leukemia, L3 Acute Lymphoblastic Leukemia, L3 Acute Lymphocytic Leukemia, FAB L3, Burkitt's Leukemia
Parent(s)
Lymphoid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.