Diseases /
Burkitt Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures. It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All cases express the MYC translocation [t(8;14)]. (WHO, 2001) [1]
Burkitt lymphomas most frequently harbor alterations in MYC, TP53, ID3, CCND3, and SMARCA4 [2].
TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, MYC Mutation, and ID3 Mutation are the most common alterations in Burkitt lymphoma [2].
Clinical Trials
Significant Genes in Burkitt Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.