Overview

NCI Definition: A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures. It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All cases express the MYC translocation [t(8;14)]. (WHO, 2001) [1]

Burkitt lymphomas most frequently harbor alterations in ID3, MYC, TP53, TCF7L2, and SMARCA4 [2].

Most Commonly Altered Genes in Burkitt Lymphoma

MYC Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 R273H are the most common alterations in Burkitt lymphoma [2].

Top Alterations in Burkitt Lymphoma

Significant Genes in Burkitt Lymphoma

ABL1 +

AFF1 +

ALK +

BCL2 +

BCL6 +

BCR +

CBFB +

DEK +

ELL +

FLT3 +

IKZF1 +

IRF4 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

MYH11 +

NPM1 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Small Non-Cleaved Cell Lymphoma, Burkitt's Type, Burkitt's Lymphoma
Parent(s)
Mature B-Cell Non-Hodgkin Lymphoma
Children
Atypical Burkitt/Burkitt-Like Lymphoma
OncoTree Name
Burkitt Lymphoma
OncoTree Code
BL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.