Diseases /
Carcinoma In Situ
Overview
NCI Definition: A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion. [1]
Carcinoma in situs most frequently harbor alterations in TP53, PIK3CA, KRAS, ESR1, and EGFR [2].
TP53 Mutation, PIK3CA Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and PIK3CA Codon 1047 Missense are the most common alterations in carcinoma in situ [2].
Clinical Trials
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.