NCI Definition: A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion. [1]

Carcinoma in situs most frequently harbor alterations in TP53, PIK3CA, KRAS, ESR1, and EGFR [2].

Most Commonly Altered Genes in Carcinoma In Situ

TP53 Mutation, PIK3CA Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and PIK3CA Codon 1047 Missense are the most common alterations in carcinoma in situ [2].

Top Alterations in Carcinoma In Situ

Disease Details

Epithelial Tumor, In situ, Malignant, CIS, CARCINOMA, IN SITU, MALIGNANT, Non-invasive Carcinoma, Intraepithelial Carcinoma, stage 0 disease
Pre-malignant Neoplasm
Adenocarcinoma In Situ, Stage 0 Esophageal Cancer AJCC v6, Stage 0 Gastric Cancer, Grade III Prostatic Intraepithelial Neoplasia, Stage 0 Laryngeal Cancer, Stage 0 Uterine Corpus Cancer AJCC v6, Cervical Carcinoma In Situ, Stage 0 Colon Cancer, Tracheal Carcinoma In Situ, Stage 0 Skin Cancer, Oral Cavity Carcinoma In Situ, Bladder Urothelial Carcinoma In Situ, Breast Carcinoma In Situ, Stage 0 Rectal Cancer, Penile Carcinoma In Situ, and Stage 0 Nasal Cavity Cancer


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.