Overview

NCI Definition: A carcinoma which has metastasized from an unknown primary anatomic site. [1]

Significant Genes in Carcinoma of Unknown Primary Origin

BRCA1 +

BRCA2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Unknown primary carcinoma (NOS), Carcinoma of unknown primary (CUP)
Parent(s)
Metastatic Carcinoma
Children
Adenocarcinoma of Unknown Primary, Squamous Cell Carcinoma of Unknown Primary, and Neuroendocrine Carcinoma of Unknown Primary

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.