Associated Genetic Biomarkers
NCI Definition: A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. 
Carcinosarcomas most frequently harbor alterations in TP53, PIK3CA, KRAS, CCNE1, and FBXW7 .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and TP53 Exon 7 Mutation are the most common alterations in carcinosarcoma .
There is 1 clinical trial for carcinosarcoma, of which 1 is open and 0 are completed or closed. Of the trial that contains carcinosarcoma as an inclusion criterion, 1 is phase 2 (1 open).
Deficient, MLH1, and MSH2 are the most frequent gene inclusion criteria for carcinosarcoma clinical trials .
Nivolumab is the most common intervention in carcinosarcoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.