NCI Definition: A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. [1]

Carcinosarcomas most frequently harbor alterations in TP53, PIK3CA, KRAS, CCNE1, and FBXW7 [2].

Most Commonly Altered Genes in Carcinosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and TP53 Exon 7 Mutation are the most common alterations in carcinosarcoma [2].

Top Alterations in Carcinosarcoma

Disease Details

Malignant Mixed Neoplasm
Lung Carcinosarcoma, Adenocarcinofibroma, Malignant Mixed Mesodermal (Mullerian) Tumor, Carcinosarcoma of Unknown Primary, Cervical Carcinosarcoma, Adenosarcoma, and Salivary Gland Carcinosarcoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.