Overview

NCI Definition: A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. [1]

Carcinosarcomas most frequently harbor alterations in TP53, CCNE1, KRAS, PIK3CA, and CEBPA [2].

Most Commonly Altered Genes in Carcinosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Nonsense, and TP53 Frameshift are the most common alterations in carcinosarcoma [2].

Top Alterations in Carcinosarcoma

Significant Genes in Carcinosarcoma

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
CARCINOSARCOMA, MALIGNANT
Parent(s)
Malignant Mixed Neoplasm
Children
Adenosarcoma, Cervical Carcinosarcoma, Malignant Mixed Mesodermal (Mullerian) Tumor, and Adenocarcinofibroma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.