NCI Definition: A malignant germ cell tumor of the central nervous system composed of large cells that proliferate in cohesive nests and sheets. In rare occasions, tumor cells may replicate the structure of the early embryo, forming "embryoid bodies" replete with germ discs and miniature amniotic cavities. Additional morphologic characteristics include enlarged nucleoli, abundant clear to somewhat violet-hued cytoplasm, a high mitotic rate and zones of coagulative necrosis. (Adapted from WHO) [1]

Central nervous system embryonal carcinomas most frequently harbor alterations in CDKN1B, RAD52, PIK3C2G, MCL1, and KRAS [2].

Most Commonly Altered Genes in Central Nervous System Embryonal Carcinoma

CDKN1B Amplification, RAD52 Amplification, PIK3C2G Amplification, MCL1 Amplification, and KRAS Amplification are the most common alterations in central nervous system embryonal carcinoma [2].

Top Alterations in Central Nervous System Embryonal Carcinoma

Disease Details

Embryonal Carcinoma of CNS, Embryonal Carcinoma of the Central Nervous System
Malignant Central Nervous System Germ Cell Tumor
Childhood Central Nervous System Embryonal Carcinoma and Adult Central Nervous System Embryonal Carcinoma
OncoTree Name
Embryonal Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.