Central Nervous System Germ Cell Tumor
NCI Definition: A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. 
Central nervous system germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, H3F3C, CCND2, and PIK3C2G .
CDKN1B Amplification, KRAS Amplification, H3F3C Amplification, CCND2 Amplification, and PIK3C2G Amplification are the most common alterations in central nervous system germ cell tumor .
There is 1 clinical trial for central nervous system germ cell tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains central nervous system germ cell tumor as an inclusion criterion, 1 is phase 2 (1 open).
Chemotherapy and radiation therapy are the most common interventions in central nervous system germ cell tumor clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.