Central Nervous System Germ Cell Tumor
NCI Definition: A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. 
Central nervous system germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, TP53, H3F3C, and CCND2 .
CDKN1B Amplification, KRAS Amplification, TP53 c.217-c.1178 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in central nervous system germ cell tumor .
There are 2 clinical trials for central nervous system germ cell tumor, of which 2 are open and 0 are completed or closed. Of the trials that contain central nervous system germ cell tumor as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
Allogeneic hematopoietic stem cell transplantation, chemotherapy, and etoposide are the most common interventions in central nervous system germ cell tumor clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.