Diseases /
Central Nervous System Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis. [1]
Central nervous system lymphomas most frequently harbor alterations in MYD88, PIM1, KMT2D, CDKN2A, and TP53 [2].
MYD88 Mutation, MYD88 L265P, MYD88 Exon 5 Mutation, PIM1 Mutation, and KMT2D Mutation are the most common alterations in central nervous system lymphoma [2].
Clinical Trials
Significant Genes in Central Nervous System Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.