Associated Genetic Biomarkers

Overview

NCI Definition: A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis. [1]

Significant Genes in Central Nervous System Lymphoma

ALK +

BRD3 +

BRD4 +

MYC +

MYCN +

Disease Details

Synonyms
Primary Central Nervous System Lymphoma, CNS Lymphoma, Malignant Lymphomas of the CNS, Primary CNS Lymphoma, PCNSL, Malignant Lymphomas of CNS
Parent(s)
Malignant Central Nervous System Neoplasm
Children
Primary Central Nervous System Lymphoma, Cerebral Lymphoma, Spinal Cord Lymphoma, and Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
OncoTree Name
Malignant Lymphoma
OncoTree Code
MLYM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.