Overview

NCI Definition: A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor. [1]

Central nervous system melanomas most frequently harbor alterations in SF3B1, GNAQ, EIF1AX, RAD50, and PRDM1 [2].

Most Commonly Altered Genes in Central Nervous System Melanoma

SF3B1 Mutation, GNAQ Q209L, GNAQ Mutation, GNAQ Exon 5 Mutation, and GNAQ Codon 209 Missense are the most common alterations in central nervous system melanoma [2].

Top Alterations in Central Nervous System Melanoma

Disease Details

Synonyms
CNS Melanoma, Melanoma of Central Nervous System, Melanoma of the CNS, Melanoma of the Central Nervous System, Melanoma of CNS
Parent(s)
Non-Cutaneous Melanoma
Children
Spinal Cord Melanoma and Meningeal Melanoma
OncoTree Name
Primary CNS Melanoma
OncoTree Code
PCNSM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.