Central Nervous System Melanoma
NCI Definition: A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor. 
Central nervous system melanomas most frequently harbor alterations in SF3B1, GNAQ, EIF1AX, RAD50, and PRDM1 .
SF3B1 Mutation, GNAQ Q209L, GNAQ Mutation, GNAQ Exon 5 Mutation, and GNAQ Codon 209 Missense are the most common alterations in central nervous system melanoma .
There is 1 clinical trial for central nervous system melanoma, of which 1 is open and 0 are completed or closed. Of the trial that contains central nervous system melanoma as an inclusion criterion, 1 is phase 1 (1 open).
Nivolumab is the most common intervention in central nervous system melanoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.