NCI Definition: A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor. [1]

Central nervous system melanomas most frequently harbor alterations in SF3B1, GNAQ, EIF1AX, RAD50, and PRDM1 [2].

Most Commonly Altered Genes in Central Nervous System Melanoma

SF3B1 Mutation, GNAQ Q209L, GNAQ Mutation, GNAQ Exon 5 Mutation, and GNAQ Codon 209 Missense are the most common alterations in central nervous system melanoma [2].

Top Alterations in Central Nervous System Melanoma

Disease Details

CNS Melanoma, Melanoma of Central Nervous System, Melanoma of the Central Nervous System, Melanoma of the CNS, Melanoma of CNS
Non-Cutaneous Melanoma
Meningeal Melanoma and Spinal Cord Melanoma
OncoTree Name
Primary CNS Melanoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.