Diseases /
Cervical Clear Cell Adenocarcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES). [1]
Cervical clear cell adenocarcinomas most frequently harbor alterations in KMT2D, WWTR1, SPOP, PTEN, and PPP2R1A [2].
KMT2D Mutation, WWTR1 S89W, SPOP Mutation, PTEN Mutation, and PIK3CA Mutation are the most common alterations in cervical clear cell adenocarcinoma [2].
Clinical Trials
Significant Genes in Cervical Clear Cell Adenocarcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.