Overview

NCI Definition: A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES). [1]

Cervical clear cell adenocarcinomas most frequently harbor alterations in KMT2D, WWTR1, SPOP, PTEN, and PPP2R1A [2].

Most Commonly Altered Genes in Cervical Clear Cell Adenocarcinoma

KMT2D Mutation, WWTR1 S89W, SPOP Mutation, PTEN Mutation, and PIK3CA Mutation are the most common alterations in cervical clear cell adenocarcinoma [2].

Top Alterations in Cervical Clear Cell Adenocarcinoma

Significant Genes in Cervical Clear Cell Adenocarcinoma

CD274 +

Disease Details

Synonyms
Clear Cell Carcinoma of the Cervix Uteri, Clear Cell Carcinoma of the Uterine Cervix, Cervical Clear Cell Carcinoma, Uterine Cervix Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma of Cervix Uteri, Clear Cell Adenocarcinoma of the Cervix, Clear Cell Adenocarcinoma of Cervix, Clear Cell Adenocarcinoma of the Uterine Cervix, Uterine Cervix Clear Cell Carcinoma, Cervix Uteri Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma of Uterine Cervix, Cervix Uteri Clear Cell Carcinoma, Clear Cell Carcinoma of the Cervix, Cervix Clear Cell Carcinoma, Clear Cell Adenocarcinoma of the Cervix Uteri, Cervix Clear Cell Adenocarcinoma, Clear Cell Carcinoma of Uterine Cervix, Clear Cell Carcinoma of Cervix Uteri, Clear Cell Carcinoma of Cervix
Parent(s)
Clear Cell Adenocarcinoma
OncoTree Name
Cervical Clear Cell Carcinoma
OncoTree Code
CECC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.