Cervical Intraepithelial Neoplasia
Associated Genetic Biomarkers
NCI Definition: Squamous or glandular intraepithelial neoplasia that affects the cervical mucosal epithelium. There is no evidence of stromal invasion. According to the degree of cellular atypia and the associated architectural changes, it is classified as low or high grade. 
There are 4 clinical trials for cervical intraepithelial neoplasia, of which 2 are open and 2 are completed or closed. Of the trials that contain cervical intraepithelial neoplasia as an inclusion criterion, 3 are phase 1 (1 open) and 1 is phase 2 (1 open).
CDKN2A, HPV, and HLA-A*02:01 are the most frequent gene inclusion criteria for cervical intraepithelial neoplasia clinical trials .
Hpv-16 e7 tcr expressing t-cells, electroporation, and pngvl4acrte6e7l2 dna vaccine are the most common interventions in cervical intraepithelial neoplasia clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.