Childhood Brain Stem Glioma
Associated Genetic Biomarkers
NCI Definition: An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location. It presents most commonly in the first two decades of life. 
Childhood brain stem gliomas most frequently harbor alterations in H3F3A, TP53, PIK3CA, HIST1H3B, and PPM1D .
H3F3A Mutation, H3F3A K28M, TP53 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in childhood brain stem glioma .
There is 1 clinical trial for childhood brain stem glioma, of which 1 is open and 0 are completed or closed. Of the trial that contains childhood brain stem glioma as an inclusion criterion, 1 is phase 1 (1 open).
Significant Genes in Childhood Brain Stem Glioma
RB1 is an inclusion eligibility criterion in 1 clinical trial for childhood brain stem glioma, of which 1 is open and 0 are closed. Of the trial that contains RB1 status and childhood brain stem glioma as inclusion criteria, 1 is phase 1 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.