Associated Genetic Biomarkers

Overview

NCI Definition: An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location. It presents most commonly in the first two decades of life. [1]

Childhood brain stem gliomas most frequently harbor alterations in H3F3A, TP53, PIK3CA, HIST1H3B, and PPM1D [2].

Most Commonly Altered Genes in Childhood Brain Stem Glioma

H3F3A Mutation, H3F3A K28M, TP53 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in childhood brain stem glioma [2].

Top Alterations in Childhood Brain Stem Glioma

Significant Genes in Childhood Brain Stem Glioma

RB1 +

Disease Details

Synonyms
Childhood Glioma of Brain Stem, Childhood Brainstem Glioma, Childhood Glioma of Brainstem, Pediatric Glioma of Brainstem, Pediatric Glioma of the Brain Stem, Pediatric Brain Stem Glioma, Childhood Glioma of the Brain Stem, Pediatric Brainstem Glioma, Childhood Glioma of the Brainstem, Pediatric Glioma of the Brainstem, Pediatric Glioma of Brain Stem
Parent(s)
Childhood Brain Stem Neoplasm
Children
Diffuse Intrinsic Pontine Glioma and Childhood Brain Stem Astrocytoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.