Diseases /
Chondrosarcoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion. [1]
Chondrosarcomas most frequently harbor alterations in IDH1, TP53, CDKN2A, CDKN2B, and IDH2 [2].
IDH1 Mutation, IDH1 Codon 132 Missense, TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in chondrosarcoma [2].
Biomarker-Directed Therapies
Clinical Trials
Significant Genes in Chondrosarcoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.