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Choroid Plexus Carcinoma

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Overview

NCI Definition: A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO) [1]

Choroid plexus carcinomas most frequently harbor alterations in TP53, XRCC1, POLQ, FGFR1, and ERCC6 [2].

Most Commonly Altered Genes in Choroid Plexus Carcinoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, XRCC1 P187L, and XRCC1 Mutation are the most common alterations in choroid plexus carcinoma [2].

Top Alterations in Choroid Plexus Carcinoma

Clinical Trials

View Clinical Trials for Choroid Plexus Carcinoma

Disease Details

Synonyms
Anaplastic Choroid Plexus Papilloma, CARCINOMA, CHOROID PLEXUS, MALIGNANT, Cancer of the Choroid Plexus, Carcinoma of the Choroid Plexus, Cancer of Choroid Plexus, Choroid Plexus Cancer, Carcinoma of Choroid Plexus
Parent(s)
Malignant Choroid Plexus Neoplasm
OncoTree Name
Choroid Plexus Carcinoma
OncoTree Code
CPC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.