Choroid Plexus Carcinoma
Associated Genetic Biomarkers
NCI Definition: A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO) 
Choroid plexus carcinomas most frequently harbor alterations in XRCC1, TP53, POLQ, FGFR1, and ERCC6 .
XRCC1 P187L, XRCC1 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, and TP53 c.1-c.137 Missense are the most common alterations in choroid plexus carcinoma .
There is 1 clinical trial for choroid plexus carcinoma, of which 1 is open and 0 are completed or closed. Of the trial that contains choroid plexus carcinoma as an inclusion criterion, 1 is phase 1 (1 open).
Therapeutic autologous lymphocytes is the most common intervention in choroid plexus carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.