Overview

NCI Definition: A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO) [1]

Choroid plexus carcinomas most frequently harbor alterations in XRCC1, TP53, POLQ, FGFR1, and ERCC6 [2].

Most Commonly Altered Genes in Choroid Plexus Carcinoma

XRCC1 P187L, XRCC1 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, and TP53 c.1-c.137 Missense are the most common alterations in choroid plexus carcinoma [2].

Top Alterations in Choroid Plexus Carcinoma

Disease Details

Synonyms
Carcinoma of the Choroid Plexus, CARCINOMA, CHOROID PLEXUS, MALIGNANT, Choroid Plexus Cancer, Cancer of Choroid Plexus, Cancer of the Choroid Plexus, Carcinoma of Choroid Plexus, Anaplastic Choroid Plexus Papilloma
Parent(s)
Malignant Choroid Plexus Neoplasm
OncoTree Name
Choroid Plexus Carcinoma
OncoTree Code
CPC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.