Choroid Plexus Carcinoma
NCI Definition: A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO) 
Choroid plexus carcinomas most frequently harbor alterations in TP53, XRCC1, POLQ, FGFR1, and ERCC6 .
TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, XRCC1 P187L, and XRCC1 Mutation are the most common alterations in choroid plexus carcinoma .
There are 3 clinical trials for choroid plexus carcinoma, of which 3 are open and 0 are completed or closed. Of the trials that contain choroid plexus carcinoma as an inclusion criterion, 3 are phase 1 (3 open).
Melphalan, allogeneic hematopoietic stem cell transplantation, and carboplatin are the most common interventions in choroid plexus carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.