Overview

NCI Definition: An intraventricular papillary neoplasm that originates from the choroid plexus epithelium. It includes the choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma. [1]

Choroid plexus neoplasms most frequently harbor alterations in TP53, IDH1, FGFR1, CIC, and ZFHX3 [2].

Most Commonly Altered Genes in Choroid Plexus Neoplasm

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, IDH1 Mutation, and TP53 Exon 8 Mutation are the most common alterations in choroid plexus neoplasm [2].

Top Alterations in Choroid Plexus Neoplasm

Significant Genes in Choroid Plexus Neoplasm

H3F3A +

MYCN +

Disease Details

Synonyms
Neoplasm of the Choroid Plexus, Choroid Plexus Tumor, Neoplasm of Choroid Plexus, Tumor of Choroid Plexus, Brain choroid plexus tumor, Tumor of the Choroid Plexus
Parent(s)
Intraventricular Brain Neoplasm
Children
Choroid Plexus Papilloma, Adult Choroid Plexus Neoplasm, Childhood Choroid Plexus Neoplasm, Malignant Choroid Plexus Neoplasm, and Atypical Choroid Plexus Papilloma
OncoTree Name
Choroid Plexus Tumor
OncoTree Code
CPT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.