NCI Definition: A type of carcinoma that comprises a minority of renal cell carcinomas. It is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics of the neoplastic cells, this type of carcinoma is classified as classic (typical) or eosinophilic. It has a much better prognosis than other renal cell carcinomas. [1]

Chromophobe renal cell carcinomas most frequently harbor alterations in TP53, PTEN, NOTCH1, SETD2, and RB1 [2].

Most Commonly Altered Genes in Chromophobe Renal Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PTEN Mutation, and TP53fs are the most common alterations in chromophobe renal cell carcinoma [2].

Top Alterations in Chromophobe Renal Cell Carcinoma

Significant Genes in Chromophobe Renal Cell Carcinoma


TFE3 +

TSC1 +

Disease Details

Chromophobe Cell Carcinoma of the Kidney, Renal Cell Carcinoma, Chromophobe Type, Chromophobe Carcinoma of the Kidney, Chromophobe Adenocarcinoma, Chromophobe Carcinoma, Chromophobe Cell Carcinoma of Kidney, Chromophobe Carcinoma of Kidney
Non-Clear Cell Renal Cell Carcinoma
Classic Variant of Chromophobe Renal Cell Carcinoma and Eosinophilic Variant of Chromophobe Renal Cell Carcinoma
OncoTree Name
Chromophobe Renal Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.