NCI Definition: A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia. 
Chronic leukemias most frequently harbor alterations in ABL1, BRAF, BCR, TET2, and ASXL1 .
BRAF V600E, BRAF Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, and BCR-ABL1 Fusion are the most common alterations in chronic leukemia .
There is 1 clinical trial for chronic leukemia, of which 0 are open and 1 is completed or closed. Of the trial that contains chronic leukemia as an inclusion criterion, 1 is phase 1 (0 open).
Nivolumab and tocilizumab are the most common interventions in chronic leukemia clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.