NCI Definition: A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia. 
Chronic leukemias most frequently harbor alterations in TP53, NOTCH1, ATM, SF3B1, and ASXL1 .
TP53 Mutation, NOTCH1 Mutation, ATM Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in chronic leukemia .
There is 1 clinical trial for chronic leukemia, of which 1 is open and 0 are completed or closed. Of the trial that contains chronic leukemia as an inclusion criterion, 1 is phase 1 (1 open).
Nivolumab and tocilizumab are the most common interventions in chronic leukemia clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.