NCI Definition: A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia. [1]

Chronic leukemias most frequently harbor alterations in TP53, NOTCH1, ATM, SF3B1, and ASXL1 [2].

Most Commonly Altered Genes in Chronic Leukemia

TP53 Mutation, NOTCH1 Mutation, ATM Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in chronic leukemia [2].

Top Alterations in Chronic Leukemia

Disease Details

T-Cell Large Granular Lymphocyte Leukemia, Hairy Cell Leukemia, Chronic Eosinophilic Leukemia, NOS, Aggressive NK-Cell Leukemia, Chronic Neutrophilic Leukemia, Hairy Cell Leukemia Variant, Prolymphocytic Leukemia, Chronic Myeloid Leukemia, and Chronic Lymphocytic Leukemia


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.