Overview

NCI Definition: An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood. [1]

Chronic lymphocytic leukemia/small lymphocytic lymphomas most frequently harbor alterations in NOTCH1, TP53, ATM, SF3B1, and KMT2D [2].

Most Commonly Altered Genes in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NOTCH1 Mutation, TP53 Mutation, ATM Mutation (germline), ATM Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in chronic lymphocytic leukemia/small lymphocytic lymphoma [2].

Top Alterations in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Significant Genes in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

ABL1 +

AFF1 +

BCR +

BTK +

CBFB +

DEK +

ELL +

FLT3 +

IGH +

IKZF1 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NUP214 +

PBX1 +

PLCG2 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Synonyms
CLL/SLL
Parent(s)
Mature B-Cell Neoplasm
Children
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation, Chronic Lymphocytic Leukemia, and Small Lymphocytic Lymphoma
OncoTree Name
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
OncoTree Code
CLLSLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.