Overview

NCI Definition: A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood. [1]

Chronic myelomonocytic leukemia-0s most frequently harbor alterations in TET2, ASXL1, SRSF2, CBL, and RUNX1 [2].

Most Commonly Altered Genes in Chronic Myelomonocytic Leukemia-0

ASXL1fs, TET2 Mutation, SRSF2 Mutation, SRSF2 Exon 1 Mutation, and SRSF2 Codon 95 Missense are the most common alterations in chronic myelomonocytic leukemia-0 [2].

Top Alterations in Chronic Myelomonocytic Leukemia-0

Significant Genes in Chronic Myelomonocytic Leukemia-0

ASXL1 +

MECOM +

MLF1 +

NPM1 +

NRAS +

RPN1 +

RUNX1 +

SETBP1 +

TP53 +

Disease Details

Synonyms
CMML-0
Parent(s)
Chronic Myelomonocytic Leukemia
OncoTree Name
Chronic Myelomonocytic Leukemia-0
OncoTree Code
CMML0

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.