Overview

NCI Definition: A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There is no detectable Philadelphia chromosome or BCR/ABL fusion gene. [1]

Chronic neutrophilic leukemias most frequently harbor alterations in RUNX1, TET2, SRSF2, IDH1, and GATA2 [2].

RUNX1 c.170-c.1439 Missense, RUNX1 Mutation, TET2 c.3400-c.4331 Missense, TET2 c.3310-c.4434 Missense, and TET2 Mutation are the most common alterations in chronic neutrophilic leukemia [2].

Significant Genes in Chronic Neutrophilic Leukemia

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.