Chronic Neutrophilic Leukemia
Associated Genetic Biomarkers
NCI Definition: A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There is no detectable Philadelphia chromosome or BCR/ABL fusion gene. 
There are 2 clinical trials for chronic neutrophilic leukemia, of which 1 is open and 1 is completed or closed. Of the trials that contain chronic neutrophilic leukemia as an inclusion criterion, 2 are phase 2 (1 open).
CSF3R is the most frequent gene inclusion criterion for chronic neutrophilic leukemia clinical trials .
Guadecitabine and ruxolitinib are the most common interventions in chronic neutrophilic leukemia clinical trials.
Significant Genes in Chronic Neutrophilic Leukemia
CSF3R is an inclusion eligibility criterion in 1 clinical trial for chronic neutrophilic leukemia, of which 0 are open and 1 is closed. Of the trial that contains CSF3R status and chronic neutrophilic leukemia as inclusion criteria, 1 is phase 2 (0 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.