NCI Definition: A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There is no detectable Philadelphia chromosome or BCR/ABL fusion gene. [1]

Chronic neutrophilic leukemias most frequently harbor alterations in RUNX1, TET2, SRSF2, IDH1, and GATA2 [2].

Most Commonly Altered Genes in Chronic Neutrophilic Leukemia

RUNX1 c.170-c.1439 Missense, RUNX1 Mutation, TET2 c.3400-c.4331 Missense, TET2 c.3310-c.4434 Missense, and TET2 Mutation are the most common alterations in chronic neutrophilic leukemia [2].

Top Alterations in Chronic Neutrophilic Leukemia

Significant Genes in Chronic Neutrophilic Leukemia


Disease Details

CNL, chronic neutrophilic leukemia, Neutrophilic Leukemia
Myeloproliferative Neoplasm
OncoTree Name
Chronic Neutrophilic Leukemia
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.