Diseases /
Classical Hodgkin Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterized by a bimodal age distribution (15-30 years of life and late life). Epstein-Barr virus has been postulated to play a role in the pathogenesis of classical Hodgkin lymphoma. Morphologically, it is characterized by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases. Four histologic subtypes have been distinguished: lymphocyte-rich, nodular sclerosis, mixed cellularity, and lymphocyte-depleted classical Hodgkin lymphoma. [1]
Classical hodgkin lymphomas most frequently harbor alterations in SOCS1, TP53, B2M, XPO1, and KMT2D [2].
TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, SOCS1fs, and XPO1 Mutation are the most common alterations in classical hodgkin lymphoma [2].
Clinical Trials
Significant Genes in Classical Hodgkin Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.