Overview

NCI Definition: A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterized by a bimodal age distribution (15-30 years of life and late life). Epstein-Barr virus has been postulated to play a role in the pathogenesis of classical Hodgkin lymphoma. Morphologically, it is characterized by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases. Four histologic subtypes have been distinguished: lymphocyte-rich, nodular sclerosis, mixed cellularity, and lymphocyte-depleted classical Hodgkin lymphoma. [1]

Classical hodgkin lymphomas most frequently harbor alterations in SOCS1, TP53, B2M, XPO1, and KMT2D [2].

Most Commonly Altered Genes in Classical Hodgkin Lymphoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, SOCS1fs, and XPO1 Mutation are the most common alterations in classical hodgkin lymphoma [2].

Top Alterations in Classical Hodgkin Lymphoma

Significant Genes in Classical Hodgkin Lymphoma

AKT1 +

AKT2 +

AKT3 +

CRKL +

MTOR +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RICTOR +

RPTOR +

TSC1 +

TSC2 +

Disease Details

Synonyms
classical Hodgkin lymphoma, Classical Hodgkin's Lymphoma, CHL, cHL, Classic Hodgkin Lymphoma
Parent(s)
Hodgkin Lymphoma
Children
Nodular Sclerosis Classical Hodgkin Lymphoma, Lymphocyte-Depleted Classical Hodgkin Lymphoma, Mixed Cellularity Classical Hodgkin Lymphoma, and Lymphocyte-Rich Classical Hodgkin Lymphoma
OncoTree Name
Classical Hodgkin Lymphoma
OncoTree Code
CHL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.