Clear Cell Adenocarcinoma
Associated Genetic Biomarkers
NCI Definition: A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid. 
Clear cell adenocarcinomas most frequently harbor alterations in VHL, PBRM1, SETD2, BAP1, and TP53 .
VHL Mutation, PBRM1fs, PBRM1 Mutation, SETD2 Mutation, and TP53 Mutation are the most common alterations in clear cell adenocarcinoma .
There is 1 clinical trial for clear cell adenocarcinoma, of which 1 is open and 0 are completed or closed. Of the trial that contains clear cell adenocarcinoma as an inclusion criterion, 1 is phase 2 (1 open).
Ipilimumab and nivolumab are the most common interventions in clear cell adenocarcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.