NCI Definition: A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid. [1]

Clear cell adenocarcinomas most frequently harbor alterations in VHL, PBRM1, SETD2, BAP1, and TP53 [2].

Most Commonly Altered Genes in Clear Cell Adenocarcinoma

VHL Mutation, PBRM1fs, PBRM1 Mutation, SETD2 Mutation, and TP53 Mutation are the most common alterations in clear cell adenocarcinoma [2].

Top Alterations in Clear Cell Adenocarcinoma

Disease Details

Clear Cell Carcinoma, Mesonephroid Clear Cell Carcinoma, ADENOCARCINOMA, CLEAR CELL, MALIGNANT, Mesonephroid Clear Cell Adenocarcinoma
Cervical Clear Cell Adenocarcinoma, Vaginal Clear Cell Adenocarcinoma, Uterine Ligament Clear Cell Adenocarcinoma, Bladder Clear Cell Adenocarcinoma, Clear Cell Renal Cell Carcinoma, Endometrial Clear Cell Adenocarcinoma, Ovarian Clear Cell Adenocarcinoma, Urethral Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Extrahepatic Bile Duct Clear Cell Adenocarcinoma, Primary Peritoneal Clear Cell Carcinoma, Hidradenocarcinoma, and Ampulla of Vater Clear Cell Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.