Overview

NCI Definition: Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. It arises from the collecting ducts of the renal medulla, and most authors suggest that this is an aggressive tumor. [1]

Collecting duct carcinomas most frequently harbor alterations in NF2 and CDKN2A [2].

Most Commonly Altered Genes in Collecting Duct Carcinoma

NF2 Mutation and NF2 Frameshift are the most common alterations in collecting duct carcinoma [2].

Top Alterations in Collecting Duct Carcinoma

Disease Details

Synonyms
Renal Collecting Duct Carcinoma, Collecting Duct Renal Cell Carcinoma, Carcinoma of the Kidney Collecting Duct, Carcinoma of the Renal Collecting Duct, Bellini Duct Carcinoma, Carcinoma of Collecting Ducts of Bellini, Kidney Collecting Duct Carcinoma, Carcinoma of the Collecting Ducts of Bellini, Collecting duct renal cancer, BDC, Carcinoma of Kidney Collecting Duct, Carcinoma of Renal Collecting Duct
Parent(s)
Non-Clear Cell Renal Cell Carcinoma
OncoTree Name
Collecting Duct Renal Cell Carcinoma
OncoTree Code
CDRCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.