NCI Definition: An invasive colorectal adenocarcinoma characterized by the presence of extracellular mucin pools that contain malignant glandular epithelial structures. The extracellular mucin pools occupy more than 50% of the malignant lesion. [1]

Colorectal mucinous adenocarcinomas most frequently harbor alterations in KRAS, APC, TP53, BRAF, and SMAD4 [2].

Most Commonly Altered Genes in Colorectal Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, APC Mutation, KRAS Codon 12 Missense, and TP53 Mutation are the most common alterations in colorectal mucinous adenocarcinoma [2].

Top Alterations in Colorectal Mucinous Adenocarcinoma

Disease Details

Mucinous Adenocarcinoma
Rectal Mucinous Adenocarcinoma, Colon Mucinous Adenocarcinoma, and Rectosigmoid Mucinous Adenocarcinoma
OncoTree Name
Mucinous Adenocarcinoma of the Colon and Rectum
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.