Overview

NCI Definition: An invasive colorectal adenocarcinoma characterized by the presence of extracellular mucin pools that contain malignant glandular epithelial structures. The extracellular mucin pools occupy more than 50% of the malignant lesion. [1]

Colorectal mucinous adenocarcinomas most frequently harbor alterations in KRAS, APC, TP53, BRAF, and PIK3CA [2].

Most Commonly Altered Genes in Colorectal Mucinous Adenocarcinoma

KRAS Mutation, APC Mutation, KRAS Exon 2 Mutation, TP53 Mutation, and KRAS Codon 12 Missense are the most common alterations in colorectal mucinous adenocarcinoma [2].

Top Alterations in Colorectal Mucinous Adenocarcinoma

Disease Details

Parent(s)
Mucinous Adenocarcinoma
Children
Colon Mucinous Adenocarcinoma, Rectosigmoid Mucinous Adenocarcinoma, and Rectal Mucinous Adenocarcinoma
OncoTree Name
Mucinous Adenocarcinoma of the Colon and Rectum
OncoTree Code
MACR

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.