Overview

NCI Definition: An invasive colorectal adenocarcinoma characterized by the presence of extracellular mucin pools that contain malignant glandular epithelial structures. The extracellular mucin pools occupy more than 50% of the malignant lesion. [1]

Colorectal mucinous adenocarcinomas most frequently harbor alterations in KRAS, APC, TP53, BRAF, and SMAD4 [2].

KRAS Mutation, KRAS Exon 2 Mutation, APC Mutation, KRAS Codon 12 Missense, and TP53 Mutation are the most common alterations in colorectal mucinous adenocarcinoma [2].

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.