NCI Definition: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [1]

Colorectal neuroendocrine carcinomas most frequently harbor alterations in TP53, APC, KRAS, RB1, and BRAF [2].

Most Commonly Altered Genes in Colorectal Neuroendocrine Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, APC Mutation, and KRAS Mutation are the most common alterations in colorectal neuroendocrine carcinoma [2].

Top Alterations in Colorectal Neuroendocrine Carcinoma

Disease Details

Colorectal NEC G3, Colorectal NEC, Colorectal (Colon or Rectal) Neuroendocrine Cancer, Large Intestinal Neuroendocrine Carcinoma, Colon neuroendocrine carcinoma
Neuroendocrine Carcinoma
Colorectal Small Cell Carcinoma and Colon Large Cell Neuroendocrine Carcinoma
OncoTree Name
High-Grade Neuroendocrine Carcinoma of the Colon and Rectum
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.