NCI Definition: A neoplasm with neuroendocrine differentiation that arises from the colon or rectum. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade). [1]

Colorectal neuroendocrine neoplasms most frequently harbor alterations in TP53, APC, KRAS, RB1, and BRAF [2].

Most Commonly Altered Genes in Colorectal Neuroendocrine Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, APC Mutation, and KRAS Mutation are the most common alterations in colorectal neuroendocrine neoplasm [2].

Top Alterations in Colorectal Neuroendocrine Neoplasm

Disease Details

Digestive System Neuroendocrine Neoplasm
Rectal Neuroendocrine Neoplasm, Colorectal Neuroendocrine Carcinoma, Colorectal Neuroendocrine Tumor, and Colon Neuroendocrine Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.