Overview

NCI Definition: A morphologic variant of small cell lung carcinoma in combination with a non-small cell carcinoma. [1]

Combined small cell lung carcinomas most frequently harbor alterations in TP53, RB1, PTEN, EGFR, and TERT [2].

Most Commonly Altered Genes in Combined Small Cell Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and RB1 Mutation are the most common alterations in combined small cell lung carcinoma [2].

Top Alterations in Combined Small Cell Lung Carcinoma

Disease Details

Synonyms
Combined Small and Large Cell Lung Carcinoma, Mixed Small Cell and Large Cell Carcinoma of the Lung, Combined Small Cell Carcinoma of the Lung, Combined Type Small Cell Lung Carcinoma, Combined Type Small Cell Carcinoma of the Lung, Mixed Small Cell and Large Cell Lung Carcinoma, Small Cell and Large Cell Lung Carcinoma, Combined Small Cell and Large Cell Lung Carcinoma, Combined Small and Large Cell Lung Cancer, Small Cell and Large Cell Carcinoma of the Lung, Mixed Small Cell and Large Cell Carcinoma of Lung, Small Cell and Large Cell Carcinoma of Lung, Combined Small Cell Carcinoma of Lung, Combined small cell carcinoma, Combined Type Small Cell Carcinoma of Lung
Parent(s)
Small Cell Lung Carcinoma
OncoTree Name
Combined Small Cell Lung Carcinoma
OncoTree Code
CSCLC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.