Overview

NCI Definition: A malignant melanoma within the conjunctiva of the eye. [1]

Conjunctival melanomas most frequently harbor alterations in TP53, NRAS, PTPN11, NTRK1, and GRIN2A [2].

Most Commonly Altered Genes in Conjunctival Melanoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, NRAS Mutation, and NRAS Exon 3 Mutation are the most common alterations in conjunctival melanoma [2].

Top Alterations in Conjunctival Melanoma

Disease Details

Synonyms
Melanoma of Conjunctiva, Malignant Melanoma of the Conjunctiva, Malignant Conjunctiva Melanoma, Melanoma of the Conjunctiva, Conjunctiva Melanoma, Malignant Conjunctival Melanoma, Malignant Melanoma of Conjunctiva
Parent(s)
Ocular Melanoma
OncoTree Name
Conjunctival Melanoma
OncoTree Code
CM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.