Overview

NCI Definition: Acute myeloid leukemia characterized by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). These cytogenetic abnormalities result in disruption of the transcription factor CBF, which is a regulator of normal hematopoiesis. [1]

Significant Genes in Core Binding Factor Acute Myeloid Leukemia

CBFB +

MYH11 +

RUNX1 +

RUNX1T1 +

Disease Details

Synonyms
CBF-AML
Parent(s)
Acute Myeloid Leukemia with Recurrent Genetic Abnormalities
Children
Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 and Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.