Associated Genetic Biomarkers
NCI Definition: An autosomal dominant hereditary syndrome characterized by a variety of hamartomas and neoplasms including verrucous skin lesions, fibromas of the oral cavity, facial trichilemmomas, hamartomatous colonic polyps, thyroid neoplasms, breast cancer, and dysplastic gangliocytomas of the cerebellum. 
There is 1 clinical trial for cowden syndrome, of which 1 is open and 0 are completed or closed. Of the trial that contains cowden syndrome as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
PTEN is the most frequent gene inclusion criterion for cowden syndrome clinical trials .
Everolimus and placebo are the most common interventions in cowden syndrome clinical trials.
Significant Genes in Cowden Syndrome
PTEN is an inclusion eligibility criterion in 1 clinical trial for cowden syndrome, of which 1 is open and 0 are closed. Of the trial that contains PTEN status and cowden syndrome as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.