Overview

NCI Definition: An atypical lipomatous tumor/well differentiated liposarcoma that shows progression to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma component may be present in the primary lesion or at the site of recurrence. [1]

Dedifferentiated liposarcomas most frequently harbor alterations in MDM2, CDK4, GLI1, TNFAIP3, and TERT [2].

Most Commonly Altered Genes in Dedifferentiated Liposarcoma

MDM2 Amplification, CDK4 Amplification, GLI1 Amplification, TNFAIP3 Amplification, and TERT Amplification are the most common alterations in dedifferentiated liposarcoma [2].

Top Alterations in Dedifferentiated Liposarcoma

Disease Details

Parent(s)
Liposarcoma
OncoTree Name
Dedifferentiated Liposarcoma
OncoTree Code
DDLS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.