Overview

NCI Definition: A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion. [1]

Desmoplastic melanomas most frequently harbor alterations in NF1, TP53, KMT2D, KMT2C, and IL7R [2].

Most Commonly Altered Genes in Desmoplastic Melanoma

NF1 Mutation, TP53 Mutation, KMT2D Mutation, NF1 Nonsense, and KMT2C Mutation are the most common alterations in desmoplastic melanoma [2].

Top Alterations in Desmoplastic Melanoma

Disease Details

Synonyms
Desmoplastic Cutaneous (Skin) Melanoma, desmoplastic melanoma
Parent(s)
Cutaneous Melanoma
OncoTree Name
Desmoplastic Melanoma
OncoTree Code
DESM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.