NCI Definition: A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion. [1]

Desmoplastic melanomas most frequently harbor alterations in NF1, TP53, KMT2D, KMT2C, and IL7R [2].

Most Commonly Altered Genes in Desmoplastic Melanoma

NF1 Mutation, TP53 Mutation, KMT2D Mutation, NF1 Nonsense, and KMT2C Mutation are the most common alterations in desmoplastic melanoma [2].

Top Alterations in Desmoplastic Melanoma

Disease Details

Desmoplastic Cutaneous (Skin) Melanoma, desmoplastic melanoma
Cutaneous Melanoma
OncoTree Name
Desmoplastic Melanoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.