NCI Definition: A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion. 
Desmoplastic melanomas most frequently harbor alterations in TP53, NF1, LRP1B, ERBB4, and KMT2D .
TP53 Mutation, NF1 Mutation, LRP1B Mutation, ERBB4 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in desmoplastic melanoma .
There is 1 clinical trial for desmoplastic melanoma, of which 1 is open and 0 are completed or closed. Of the trial that contains desmoplastic melanoma as an inclusion criterion, 1 is phase 2 (1 open).
Pembrolizumab and surgery are the most common interventions in desmoplastic melanoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.