Overview

NCI Definition: An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration. [1]

Diffuse gastric adenocarcinomas most frequently harbor alterations in TP53 and CDH1 [2].

Most Commonly Altered Genes in Diffuse Gastric Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and CDH1 Mutation are the most common alterations in diffuse gastric adenocarcinoma [2].

Top Alterations in Diffuse Gastric Adenocarcinoma

Significant Genes in Diffuse Gastric Adenocarcinoma

ERBB2 +

Disease Details

Synonyms
Adenocarcinoma of Linitis Plastica Type, Diffuse Adenocarcinoma of the Stomach, Diffuse Adenocarcinoma of Stomach, Adenocarcinoma of the Linitis Plastica Type, Diffuse Stomach Adenocarcinoma
Parent(s)
Gastric Adenocarcinoma
OncoTree Name
Diffuse Type Stomach Adenocarcinoma
OncoTree Code
DSTAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.