Overview

NCI Definition: A neuroglial tumor that arises from the middle portion of the brain stem. It usually affects children and has a poor prognosis. [1]

Significant Genes in Diffuse Intrinsic Pontine Glioma

EGFR +

ERBB2 +

ERBB4 +

H3F3A +

HGF +

MET +

MYCN +

PDGFA +

PDGFB +

PDGFRA +

PDGFRB +

RB1 +

Disease Details

Synonyms
DIPG, diffuse intrinsic pontine glioma
Parent(s)
Diffuse Midline Glioma, H3 K27M-Mutant
OncoTree Name
Diffuse Intrinsic Pontine Glioma
OncoTree Code
DIPG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.