Overview

NCI Definition: A neuroglial tumor that arises from the middle portion of the brain stem. It usually affects children and has a poor prognosis. [1]

Diffuse intrinsic pontine gliomas most frequently harbor alterations in H3F3A, TP53, PIK3CA, SPTA1, and SETBP1 [2].

Most Commonly Altered Genes in Diffuse Intrinsic Pontine Glioma

H3F3A K28M, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Mutation are the most common alterations in diffuse intrinsic pontine glioma [2].

Top Alterations in Diffuse Intrinsic Pontine Glioma

Significant Genes in Diffuse Intrinsic Pontine Glioma

FGF1 +

FGF3 +

FGFR1 +

FGFR3 +

H3F3A +

HGF +

MET +

PDGFA +

PDGFB +

PDGFRA +

PDGFRB +

Disease Details

Synonyms
diffuse intrinsic pontine glioma, DIPG
Parent(s)
Childhood Brain Stem Glioma
OncoTree Name
Diffuse Intrinsic Pontine Glioma
OncoTree Code
DIPG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.