NCI Definition: A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma. [1]

Digestive system carcinomas most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Digestive System Carcinoma

TP53 Mutation, APC Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Mutation are the most common alterations in digestive system carcinoma [2].

Top Alterations in Digestive System Carcinoma

Significant Genes in Digestive System Carcinoma


UGT1A1 +

Disease Details

Malignant Digestive System Neoplasm
Pancreatobiliary Carcinoma, Anal Carcinoma, Esophagogastric Carcinoma, Small Intestinal Carcinoma, Colorectal Carcinoma, Appendix Carcinoma, and Liver and Intrahepatic Bile Duct Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.