Digestive System Carcinoma
Associated Genetic Biomarkers
NCI Definition: A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma. 
Digestive system carcinomas most frequently harbor alterations in TP53, KRAS, CDKN2A, SMAD4, and ARID1A .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in digestive system carcinoma .
There are 2 clinical trials for digestive system carcinoma, of which 2 are open and 0 are completed or closed. Of the trials that contain digestive system carcinoma as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
ERBB2 and UGT1A1 are the most frequent gene inclusion criteria for digestive system carcinoma clinical trials .
Irinotecan and trastuzumab are the most common interventions in digestive system carcinoma clinical trials.
Significant Genes in Digestive System Carcinoma
ERBB2 is mutated in 13.18% of digestive system carcinoma patients .
ERBB2 is an inclusion eligibility criterion in 1 clinical trial for digestive system carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 status and digestive system carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Irinotecan and trastuzumab are the most frequent therapies in digestive system carcinoma trials with ERBB2 mutations as inclusion criteria .
UGT1A1 is an inclusion eligibility criterion in 1 clinical trial for digestive system carcinoma, of which 1 is open and 0 are closed. Of the trial that contains UGT1A1 status and digestive system carcinoma as inclusion criteria, 1 is phase 1 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.