Overview

NCI Definition: A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma. [1]

Digestive system carcinomas most frequently harbor alterations in TP53, KRAS, CDKN2A, ARID1A, and ERBB2 [2].

Most Commonly Altered Genes in Digestive System Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in digestive system carcinoma [2].

Top Alterations in Digestive System Carcinoma

Significant Genes in Digestive System Carcinoma

ERBB2 +

Disease Details

Parent(s)
Malignant Digestive System Neoplasm
Children
Anal Carcinoma, Appendix Carcinoma, Colorectal Carcinoma, Small Intestinal Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Esophagogastric Carcinoma, Ampulla of Vater Carcinoma, and Biliary Tract Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.