NCI Definition: A benign or malignant neoplasm involving any part of the digestive system. [1]

Digestive system neoplasms most frequently harbor alterations in TP53, KRAS, APC, SMAD4, and PIK3CA [2].

Most Commonly Altered Genes in Digestive System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in digestive system neoplasm [2].

Top Alterations in Digestive System Neoplasm

Disease Details

Digestive System Disorder
Benign Gastrointestinal System Neoplasm, Digestive System Adenoma, Malignant Digestive System Neoplasm, Pancreatic Neoplasm, Gastrointestinal Stromal Tumor, Hepatobiliary Neoplasm, Ampulla of Vater Neoplasm, Appendix Neoplasm, Gastric Germ Cell Tumor, Anal Neoplasm, Digestive System Neuroendocrine Neoplasm, and Intestinal Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.