NCI Definition: A benign or malignant neoplasm involving any part of the digestive system. [1]

Digestive system neoplasms most frequently harbor alterations in TP53, KRAS, APC, SMAD4, and PIK3CA [2].

Most Commonly Altered Genes in Digestive System Neoplasm

TP53 Mutation, KRAS Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Exon 2 Mutation are the most common alterations in digestive system neoplasm [2].

Top Alterations in Digestive System Neoplasm

Disease Details

Solid Neoplasm
Gastrointestinal Stromal Tumor, Gastrointestinal Stromal Tumor of the Gastrointestinal Tract, Hepatobiliary Neoplasm, Digestive System Neuroendocrine Neoplasm, Benign Gastrointestinal System Neoplasm, Appendix Neoplasm, Esophagogastric Neoplasm, Intestinal Neoplasm, Ampulla of Vater Neoplasm, Malignant Digestive System Neoplasm, Anal Neoplasm, Pancreatic Neoplasm, and Digestive System Adenoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.