Overview

NCI Definition: A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas). [1]

Digestive system neuroendocrine neoplasms most frequently harbor alterations in TP53, APC, KRAS, RB1, and CDKN1B [2].

Most Commonly Altered Genes in Digestive System Neuroendocrine Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, APC Mutation, and KRAS Mutation are the most common alterations in digestive system neuroendocrine neoplasm [2].

Top Alterations in Digestive System Neuroendocrine Neoplasm

Disease Details

Synonyms
Gastrointestinal Neuroendocrine Neoplasm, Gastrointestinal System Neuroendocrine Neoplasm
Parent(s)
Neuroendocrine Neoplasm
Children
Small Intestinal Neuroendocrine Neoplasm, Extrahepatic Bile Duct Neuroendocrine Carcinoma, Ampulla of Vater Small Cell Neuroendocrine Carcinoma, Pancreatic Neuroendocrine Neoplasm, Colorectal Neuroendocrine Neoplasm, Gastrointestinal Neuroendocrine Tumors, Gallbladder Small Cell Neuroendocrine Carcinoma, Esophageal Neuroendocrine Neoplasm, and Gastric Neuroendocrine Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.