NCI Definition: A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas). [1]

Digestive system neuroendocrine neoplasms most frequently harbor alterations in TP53, APC, KRAS, RB1, and CDKN1B [2].

Most Commonly Altered Genes in Digestive System Neuroendocrine Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, APC Mutation, and KRAS Mutation are the most common alterations in digestive system neuroendocrine neoplasm [2].

Top Alterations in Digestive System Neuroendocrine Neoplasm

Disease Details

Gastrointestinal Neuroendocrine Neoplasm, Gastrointestinal System Neuroendocrine Neoplasm
Neuroendocrine Neoplasm
Gallbladder Small Cell Neuroendocrine Carcinoma, Small Intestinal Neuroendocrine Neoplasm, Extrahepatic Bile Duct Neuroendocrine Carcinoma, Pancreatic Neuroendocrine Neoplasm, Gastrointestinal Neuroendocrine Tumors, Colorectal Neuroendocrine Neoplasm, Esophageal Neuroendocrine Neoplasm, Gastric Neuroendocrine Neoplasm, Ampulla of Vater Small Cell Neuroendocrine Carcinoma, and Anal Canal Neuroendocrine Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.