Overview

NCI Definition: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS. [1]

Ductal carcinoma in situs most frequently harbor alterations in TP53, PIK3CA, FGFR1, CCND1, and ZNF703 [2].

Most Commonly Altered Genes in Ductal Carcinoma In Situ

TP53 Mutation, PIK3CA Mutation (somatic), PIK3CA Mutation, TP53 c.217-c.1178 Missense, and TP53 c.142-c.212 Missense are the most common alterations in ductal carcinoma in situ [2].

Top Alterations in Ductal Carcinoma In Situ

Significant Genes in Ductal Carcinoma In Situ

BRCA1 +

BRCA2 +

ERBB2 +

Disease Details

Synonyms
Non-Infiltrating Ductal Carcinoma of Breast, Ductal Carcinoma In Situ of Breast, Non-Infiltrating Intraductal Adenocarcinoma of the Breast, Non-Invasive Ductal Carcinoma of the Breast, Non-Infiltrating Ductal Carcinoma of the Breast, Non-Infiltrating Intraductal Adenocarcinoma, Non-Infiltrating Ductal Breast Carcinoma, Non-Infiltrating Intraductal Adenocarcinoma of Breast, Non-Invasive Ductal Adenocarcinoma of the Breast, Non-Invasive Ductal Adenocarcinoma of Breast, Non-Infiltrating Ductal Adenocarcinoma of Breast, Non-Invasive Ductal Breast Carcinoma, Non-Invasive Intraductal Breast Adenocarcinoma, Non-Infiltrating Intraductal Breast Adenocarcinoma, Non-Invasive Intraductal Adenocarcinoma of Breast, Intraductal Breast Carcinoma, DCIS, Non-Infiltrating Ductal Breast Adenocarcinoma, Non-Infiltrating Intraductal Carcinoma, Non-Infiltrating Ductal Adenocarcinoma of the Breast, Ductal Carcinoma In Situ (DCIS), intraductal carcinoma, Intraductal Carcinoma of Breast, Non-Invasive Intraductal Adenocarcinoma of the Breast, Ductal Breast Carcinoma In Situ, ductal carcinoma in situ, Non-Invasive Ductal Breast Adenocarcinoma, Ductal Carcinoma In Situ of the Breast, Intraductal Carcinoma of the Breast, Non-Invasive Ductal Carcinoma of Breast
Parent(s)
Breast Ductal Carcinoma
Children
Apocrine Breast Carcinoma In Situ
OncoTree Name
Breast Ductal Carcinoma In Situ
OncoTree Code
DCIS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.