Ductal Carcinoma In Situ

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Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS. [1]

Clinical Trials

View Clinical Trials for Ductal Carcinoma In Situ

Significant Genes in Ductal Carcinoma In Situ

BRCA1 +

BRCA2 +

ERBB2 +

Disease Details

Synonyms

Non-Invasive Intraductal Adenocarcinoma of the Breast, Non-Invasive Ductal Carcinoma of the Breast, Non-Invasive Ductal Adenocarcinoma of Breast, Intraductal Carcinoma of the Breast, Ductal Carcinoma In Situ of Breast, Non-Invasive Ductal Breast Adenocarcinoma, Ductal Breast Carcinoma In Situ, Intraductal Breast Carcinoma, Non-Infiltrating Intraductal Adenocarcinoma of the Breast, Non-Invasive Ductal Breast Carcinoma, Non-Infiltrating Intraductal Breast Adenocarcinoma, Non-Infiltrating Ductal Adenocarcinoma of the Breast, ductal carcinoma in situ, Non-Infiltrating Intraductal Adenocarcinoma of Breast, Non-Infiltrating Ductal Breast Adenocarcinoma, Non-Infiltrating Ductal Breast Carcinoma, Non-Invasive Intraductal Breast Adenocarcinoma, intraductal carcinoma, Non-Invasive Ductal Adenocarcinoma of the Breast, Ductal Carcinoma In Situ (DCIS), Non-Infiltrating Ductal Carcinoma of the Breast, DCIS, Non-Infiltrating Intraductal Adenocarcinoma, Intraductal Carcinoma of Breast, Non-Infiltrating Ductal Adenocarcinoma of Breast, Ductal Carcinoma In Situ of the Breast, Non-Infiltrating Ductal Carcinoma of Breast, Non-Infiltrating Intraductal Carcinoma, Non-Invasive Ductal Carcinoma of Breast, Non-Invasive Intraductal Adenocarcinoma of Breast

Parent(s)

Breast Ductal Carcinoma

Children

Comedocarcinoma and Apocrine Breast Carcinoma In Situ

OncoTree Name

Breast Ductal Carcinoma In Situ

OncoTree Code

DCIS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.

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