Endometrial Adenocarcinoma

Back to Diseases List

Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma. [1]

Endometrial adenocarcinomas most frequently harbor alterations in PTEN, PIK3CA, TP53, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Endometrial Adenocarcinoma

PTEN Mutation, PIK3CA Mutation, TP53 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in endometrial adenocarcinoma [2].

Top Alterations in Endometrial Adenocarcinoma

Biomarker-Directed Therapies

View Therapies for Endometrial Adenocarcinoma

Of the biomarker-directed therapies for endometrial adenocarcinoma, 0 are FDA-approved in at least one setting and 2 have NCCN guidelines in at least one setting [3].

Nivolumab +

Trastuzumab +

Clinical Trials

View Clinical Trials for Endometrial Adenocarcinoma

Significant Genes in Endometrial Adenocarcinoma

BRCA1 +

BRCA2 +

ERBB2 +

POLE +

Disease Details

Synonyms

UTERUS ENDOMETRIAL ADENOCARCINOMA (NOS), Metastatic adenocarcinoma, c/w endometrial primary, Adenocarcinoma of Endometrium, Adenocarcinoma of the Endometrium, Adenocarcinoma c/w Uterine Primary, Adenocarcinoma c/w Endometrial Primary, ADENOCARCINOMA, ENDOMETRIAL, MALIGNANT

Parent(s)

Endometrial Carcinoma

Children

Endometrial Mixed Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Mucinous Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, and Endometrial Serous Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.

Diseases /