NCI Definition: A rare endometrial carcinoma characterized by the presence of both malignant glandular and malignant squamous cellular components. [1]

Endometrial adenosquamous carcinomas most frequently harbor alterations in PIK3CA, TP53, PTEN, VHL, and STK11 [2].

Most Commonly Altered Genes in Endometrial Adenosquamous Carcinoma

PIK3CA Mutation, TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, and TP53 Exon 8 Mutation are the most common alterations in endometrial adenosquamous carcinoma [2].

Top Alterations in Endometrial Adenosquamous Carcinoma

Disease Details

Endometrial Carcinoma
OncoTree Name
Uterine Adenosquamous Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.