Diseases /
Endometrial Clear Cell Adenocarcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A high-grade endometrial adenocarcinoma characterized by the presence of large neoplastic cells that display at least focal cytoplasmic clearing. The neoplastic cells form papillary, glandular, or sheet-like structures. [1]
Endometrial clear cell adenocarcinomas most frequently harbor alterations in TP53, PIK3CA, ARID1A, PPP2R1A, and SPOP [2].
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, PIK3CA Mutation, and PPP2R1A Mutation are the most common alterations in endometrial clear cell adenocarcinoma [2].
Clinical Trials
Significant Genes in Endometrial Clear Cell Adenocarcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.