Overview

NCI Definition: A high-grade endometrial adenocarcinoma characterized by the presence of large neoplastic cells that display at least focal cytoplasmic clearing. The neoplastic cells form papillary, glandular, or sheet-like structures. [1]

Endometrial clear cell adenocarcinomas most frequently harbor alterations in TP53, PIK3CA, ARID1A, SPOP, and FBXW7 [2].

Most Commonly Altered Genes in Endometrial Clear Cell Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in endometrial clear cell adenocarcinoma [2].

Top Alterations in Endometrial Clear Cell Adenocarcinoma

Significant Genes in Endometrial Clear Cell Adenocarcinoma

MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Synonyms
Clear Cell Carcinoma of Endometrium, Clear Cell Carcinoma of the Endometrium
Parent(s)
Endometrial Adenocarcinoma
OncoTree Name
Uterine Clear Cell Carcinoma
OncoTree Code
UCCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.