NCI Definition: A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma. [1]

Endometrial dedifferentiated carcinomas most frequently harbor alterations in PTEN, ARID1A, PIK3CA, KMT2B, and ARID1B [2].

Most Commonly Altered Genes in Endometrial Dedifferentiated Carcinoma

PTEN Mutation, PIK3CA Mutation, ARID1fs, SMARCA4 Mutation, and KMT2B Mutation are the most common alterations in endometrial dedifferentiated carcinoma [2].

Top Alterations in Endometrial Dedifferentiated Carcinoma

Disease Details

Endometrial Carcinoma
OncoTree Name
Uterine Dedifferentiated Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.