Overview

NCI Definition: A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma. [1]

Endometrial dedifferentiated carcinomas most frequently harbor alterations in PTEN, ARID1A, ARID1B, and PIK3CA [2].

Most Commonly Altered Genes in Endometrial Dedifferentiated Carcinoma

PTEN Mutation, ARID1A Mutation, ARID1A Frameshift, ARID1B Mutation, and PIK3CA Mutation are the most common alterations in endometrial dedifferentiated carcinoma [2].

Top Alterations in Endometrial Dedifferentiated Carcinoma

Disease Details

Parent(s)
Endometrial Carcinoma
OncoTree Name
Uterine Dedifferentiated Carcinoma
OncoTree Code
UDDC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.